Indicator type;Size of the company;Total Number of companies carrying out R&D in Biotechnology;Less than 250 employees;1.221 Number of companies carrying out R&D in Biotechnology;250 and more employees;156 Number of companies carrying out R&D in Biotechnology;Total;1.376 % Companies by type of biotechnology used: Genetic Code;Less than 250 employees;30,2 % Companies by type of biotechnology used: Genetic Code;250 and more employees;41,5 % Companies by type of biotechnology used: Genetic Code;Total;31,4 % Companies by type of biotechnology used: Functional Units;Less than 250 employees;42,4 % Companies by type of biotechnology used: Functional Units;250 and more employees;54,3 % Companies by type of biotechnology used: Functional Units;Total;43,7 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;Less than 250 employees;21,2 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;250 and more employees;35,9 % Companies by type of biotechnology used: Cell and Tissue Culture and Engineering;Total;22,8 % Companies by type of biotechnology used: Bioprocesses;Less than 250 employees;46,1 % Companies by type of biotechnology used: Bioprocesses;250 and more employees;65,3 % Companies by type of biotechnology used: Bioprocesses;Total;48,3 % Companies by type of biotechnology used: Subcellular Organisms;Less than 250 employees;7 % Companies by type of biotechnology used: Subcellular Organisms;250 and more employees;14,6 % Companies by type of biotechnology used: Subcellular Organisms;Total;7,9 % Companies by type of biotechnology used: Bioinformatics;Less than 250 employees;26,5 % Companies by type of biotechnology used: Bioinformatics;250 and more employees;32,5 % Companies by type of biotechnology used: Bioinformatics;Total;27,1 % Companies by type of biotechnology used: Nanobiotechnology;Less than 250 employees;11 % Companies by type of biotechnology used: Nanobiotechnology;250 and more employees;13,4 % Companies by type of biotechnology used: Nanobiotechnology;Total;11,2 % Companies by type of biotechnology used: Other;Less than 250 employees;18,1 % Companies by type of biotechnology used: Other;250 and more employees;14 % Companies by type of biotechnology used: Other;Total;17,6 Companies in which biotechnology activities are: Main and/or exclusive;Less than 250 employees;686 Companies in which biotechnology activities are: Main and/or exclusive;250 and more employees;25 Companies in which biotechnology activities are: Main and/or exclusive;Total;711 Companies in which biotechnology activities are: A secondary business line;Less than 250 employees;214 Companies in which biotechnology activities are: A secondary business line;250 and more employees;55 Companies in which biotechnology activities are: A secondary business line;Total;270 Companies in which biotechnology activities are: A necessary tool for production;Less than 250 employees;320 Companies in which biotechnology activities are: A necessary tool for production;250 and more employees;75 Companies in which biotechnology activities are: A necessary tool for production;Total;395 % Companies by final application areas of biotechnology use: Human Health;Less than 250 employees;48,7 % Companies by final application areas of biotechnology use: Human Health;250 and more employees;42,7 % Companies by final application areas of biotechnology use: Human Health;Total;48 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;Less than 250 employees;16,7 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;250 and more employees;17,9 % Companies by final application areas of biotechnology use: Animal Health and Aquaculture;Total;16,9 % Companies by final application areas of biotechnology use: Food Products;Less than 250 employees;28 % Companies by final application areas of biotechnology use: Food Products;250 and more employees;40,1 % Companies by final application areas of biotechnology use: Food Products;Total;29,4 % Companies by final application areas of biotechnology use: Agriculture and Forestry;Less than 250 employees;26,1 % Companies by final application areas of biotechnology use: Agriculture and Forestry;250 and more employees;22,6 % Companies by final application areas of biotechnology use: Agriculture and Forestry;Total;25,7 % Companies by final application areas of biotechnology use: Environment;Less than 250 employees;17,9 % Companies by final application areas of biotechnology use: Environment;250 and more employees;18,9 % Companies by final application areas of biotechnology use: Environment;Total;18 % Companies by final application areas of biotechnology use: Industry;Less than 250 employees;12,6 % Companies by final application areas of biotechnology use: Industry;250 and more employees;16,5 % Companies by final application areas of biotechnology use: Industry;Total;13 R&D personnel in Biotechnology (PP);Less than 250 employees;10.421 R&D personnel in Biotechnology (PP);250 and more employees;6.836 R&D personnel in Biotechnology (PP);Total;17.257 R&D personnel in Biotechnology (PP): Research personnel;Less than 250 employees;6.087 R&D personnel in Biotechnology (PP): Research personnel;250 and more employees;3.108 R&D personnel in Biotechnology (PP): Research personnel;Total;9.195 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;Less than 250 employees;4.333 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;250 and more employees;3.728 R&D personnel in Biotechnology (PP): Technical and auxiliary personnel;Total;8.061 R&D personnel in Biotechnology (PP). Women;Less than 250 employees;5.700 R&D personnel in Biotechnology (PP). Women;250 and more employees;4.280 R&D personnel in Biotechnology (PP). Women;Total;9.980 R&D personnel in Biotechnology (PP). Women: Research personnel;Less than 250 employees;3.359 R&D personnel in Biotechnology (PP). Women: Research personnel;250 and more employees;1.863 R&D personnel in Biotechnology (PP). Women: Research personnel;Total;5.222 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;Less than 250 employees;2.341 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;250 and more employees;2.417 R&D personnel in Biotechnology (PP). Women: Technical and auxiliary personnel;Total;4.758 R&D personnel in Biotechnology (FTE);Less than 250 employees;7.562,8 R&D personnel in Biotechnology (FTE);250 and more employees;5.320,6 R&D personnel in Biotechnology (FTE);Total;12.883,4 R&D personnel in Biotechnology (FTE): Research personnel;Less than 250 employees;4.665,3 R&D personnel in Biotechnology (FTE): Research personnel;250 and more employees;2.437,9 R&D personnel in Biotechnology (FTE): Research personnel;Total;7.103,2 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;Less than 250 employees;2.897,4 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;250 and more employees;2.882,8 R&D personnel in Biotechnology (FTE): Technical and auxiliary personnel;Total;5.780,2 R&D personnel in Biotechnology (FTE). Women;Less than 250 employees;4.222 R&D personnel in Biotechnology (FTE). Women;250 and more employees;3.378,6 R&D personnel in Biotechnology (FTE). Women;Total;7.600,6 R&D personnel in Biotechnology (FTE). Women: Research personnel;Less than 250 employees;2.605,7 R&D personnel in Biotechnology (FTE). Women: Research personnel;250 and more employees;1.451,3 R&D personnel in Biotechnology (FTE). Women: Research personnel;Total;4.057 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;Less than 250 employees;1.616,3 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;250 and more employees;1.927,3 R&D personnel in Biotechnology (FTE). Women: Technical and auxiliary personnel;Total;3.543,7 Expenditure on internal R&D in Biotechnology (thousands of euros);Less than 250 employees;794.091 Expenditure on internal R&D in Biotechnology (thousands of euros);250 and more employees;489.255 Expenditure on internal R&D in Biotechnology (thousands of euros);Total;1.283.346 1) By type of expenditure: Current expenditure;Less than 250 employees;715.652 1) By type of expenditure: Current expenditure;250 and more employees;464.535 1) By type of expenditure: Current expenditure;Total;1.180.187 1.1) Labour expenditure of research personnel;Less than 250 employees;235.238 1.1) Labour expenditure of research personnel;250 and more employees;137.183 1.1) Labour expenditure of research personnel;Total;372.421 1.2) Labour expenditure of technical and auxiliary personnel;Less than 250 employees;113.075 1.2) Labour expenditure of technical and auxiliary personnel;250 and more employees;116.659 1.2) Labour expenditure of technical and auxiliary personnel;Total;229.734 1.3) Other current expenditure;Less than 250 employees;367.339 1.3) Other current expenditure;250 and more employees;210.693 1.3) Other current expenditure;Total;578.032 2) By type of expenditure: Capital expenditure;Less than 250 employees;78.439 2) By type of expenditure: Capital expenditure;250 and more employees;24.720 2) By type of expenditure: Capital expenditure;Total;103.159 2.1) Land and buildings;Less than 250 employees;8.547 2.1) Land and buildings;250 and more employees;2.342 2.1) Land and buildings;Total;10.889 2.2) Equipment and tools;Less than 250 employees;40.395 2.2) Equipment and tools;250 and more employees;18.809 2.2) Equipment and tools;Total;59.204 2.3) Acquisition of specific R&D software;Less than 250 employees;4.415 2.3) Acquisition of specific R&D software;250 and more employees;1.208 2.3) Acquisition of specific R&D software;Total;5.623 2.4) Other R&D-specific IP products;Less than 250 employees;25.082 2.4) Other R&D-specific IP products;250 and more employees;2.360 2.4) Other R&D-specific IP products;Total;27.442 1.1) By origin of funds: Own funds;Less than 250 employees;548.276 1.1) By origin of funds: Own funds;250 and more employees;339.251 1.1) By origin of funds: Own funds;Total;887.527 1.2) By origin of funds: Funds from the Business sector;Less than 250 employees;96.237 1.2) By origin of funds: Funds from the Business sector;250 and more employees;47.667 1.2) By origin of funds: Funds from the Business sector;Total;143.903 1.3) By origin of funds: Funds from the Public Administration sector;Less than 250 employees;98.923 1.3) By origin of funds: Funds from the Public Administration sector;250 and more employees;27.623 1.3) By origin of funds: Funds from the Public Administration sector;Total;126.546 1.4) By origin of funds: Funds from the Higher Education sector;Less than 250 employees;94 1.4) By origin of funds: Funds from the Higher Education sector;250 and more employees;0 1.4) By origin of funds: Funds from the Higher Education sector;Total;94 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;Less than 250 employees;2.684 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;250 and more employees;9.939 1.5) By origin of funds: Funds from the Private Non-Profit Institutions sector;Total;12.623 1.6) By origin of funds: Funds from the rest of the world;Less than 250 employees;47.877 1.6) By origin of funds: Funds from the rest of the world;250 and more employees;64.776 1.6) By origin of funds: Funds from the rest of the world;Total;112.652 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);Less than 250 employees;76.773 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);250 and more employees;60.659 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros);Total;137.432 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;Less than 250 employees;38.607 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;250 and more employees;49.521 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In Spain;Total;88.127 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;Less than 250 employees;38.166 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;250 and more employees;11.139 Purchase of R&D services (external R&D) in Biotechnology (thousands of euros): In the rest of the world;Total;49.305 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;Less than 250 employees;46,3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;250 and more employees;23,2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to capital;Total;43,7 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;Less than 250 employees;16,3 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;250 and more employees;15,5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to technology/information;Total;16,2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;Less than 250 employees;24,6 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;250 and more employees;16 % Companies that consider the following obstacles to the development of biotechnologies as very important: Access to human resources;Total;23,7 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;Less than 250 employees;14,4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;250 and more employees;14,5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Disconnection from the value chain;Total;14,5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;Less than 250 employees;19 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;250 and more employees;10,5 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of access to international markets;Total;18,1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;Less than 250 employees;20,4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;250 and more employees;12,9 % Companies that consider the following obstacles to the development of biotechnologies as very important: Lack of distribution and marketing channels;Total;19,6 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;Less than 250 employees;18,9 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;250 and more employees;21,2 % Companies that consider the following obstacles to the development of biotechnologies as very important: Public acceptance/perception;Total;19,1 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;Less than 250 employees;51 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;250 and more employees;40,8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Legal and regulatory requirements;Total;49,8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;Less than 250 employees;61 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;250 and more employees;46,8 % Companies that consider the following obstacles to the development of biotechnologies as very important: Time/cost;Total;59,4 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;Less than 250 employees;23,7 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;250 and more employees;11 % Companies that consider the following obstacles to the development of biotechnologies as very important: Difficult access to patenting;Total;22,3 % Companies with international revenues related to biotechnology activities;Less than 250 employees;23,6 % Companies with international revenues related to biotechnology activities;250 and more employees;22,7 % Companies with international revenues related to biotechnology activities;Total;23,6 % Companies representing international revenues related to biotechnology activities;Less than 250 employees;6,9 % Companies representing international revenues related to biotechnology activities;250 and more employees;1 % Companies representing international revenues related to biotechnology activities;Total;1,5 % International revenues related to biotechnology activities distributed in: Revenues from the EU;Less than 250 employees;50 % International revenues related to biotechnology activities distributed in: Revenues from the EU;250 and more employees;62,8 % International revenues related to biotechnology activities distributed in: Revenues from the EU;Total;57,6 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;Less than 250 employees;50 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;250 and more employees;37,2 % International revenues related to biotechnology activities distributed in: Revenues from the rest of the world;Total;42,4 % International revenues related to biotechnology activities by classification: International trade in goods and services;Less than 250 employees;91,4 % International revenues related to biotechnology activities by classification: International trade in goods and services;250 and more employees;76,2 % International revenues related to biotechnology activities by classification: International trade in goods and services;Total;82,3 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Less than 250 employees;4,5 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;250 and more employees;20,6 % International revenues related to biotechnology activities by classification: Milestones, royalties, sale or licensing of technologies outside Spain;Total;14,1 % International revenues related to biotechnology activities by classification: Subsidies from external sources;Less than 250 employees;1 % International revenues related to biotechnology activities by classification: Subsidies from external sources;250 and more employees;1,8 % International revenues related to biotechnology activities by classification: Subsidies from external sources;Total;1,5 % International revenues related to biotechnology activities by classification: Other;Less than 250 employees;3,1 % International revenues related to biotechnology activities by classification: Other;250 and more employees;1,4 % International revenues related to biotechnology activities by classification: Other;Total;2,1